p53 genes การใช้

• At the same time, Epstein was intrigued by the p53 gene.
• In nonsmokers, only 14 percent of tumors had damaged p53 genes.
• In most cancer patients, the p53 gene is defective.
• The p53 gene is known as the tumor suppressor gene.
• Only when the p53 gene mutates does the tumor spin out of control.
• She passed the mutant p53 gene to both daughters.
• Without this gene, it should infect only cells with damaged p53 genes.
• It delivers a functional copy of the p53 gene using an engineered adenovirus.
• However, a larger series of 12 cases revealed no p53 gene mutations.
• They found damage, or mutations, in 42 percent of the p53 genes.
• When p53 genes are damaged, the body becomes much more susceptible to cancer.
• Some, like the p53 gene, turn the signal down, suppressing growth.
• In many types of cancer cells, the p53 gene is damaged by mutation.
• The p53 gene is the single most commonly mutated gene in cancers of humans,
• Many cancer cells sabotage their own p53 gene directly and others do so indirectly.
• In Roth's laboratory, workers combine a retrovirus with the normal p53 gene.
• In 1982 biologists isolated the p53 gene.
• But even a cell whose healthy p53 gene stays that way can be in trouble.
• Defects in the p53 gene have been implicated in more than half of all cancers.
• Examples of tumor-specific antigens include the abnormal products of ras and p53 genes.